Active-Site Dynamics in RNA Polymerases
نویسنده
چکیده
New crystal structures of transcription complexes formed by bacteriophage T7 RNA polymerase reveal a nucleotide-addition cycle driven by active-site conformational changes similar to those observed in DNA polymerases, and suggest provocative hypotheses for the more complex multisubunit RNA polymerases of free-living organisms.
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ورودعنوان ژورنال:
- Cell
دوره 116 شماره
صفحات -
تاریخ انتشار 2004